DISORDERS  OF  ODOR  PERCEPTION

A  Compendium  of  News  &  Clinical  Science

Covering Advances in  •   Anosmia  •   Hyposmia   •  Parosmia   •   Phantosmia

Smell Loss

Nasal trauma impairs olfaction only when associated with nasal fracture. Read more »


A nationwide cohort study in South Korea finds olfactory dysfunction higher in women, increasing in prevalence, and associated with diabetes and depression. Read more »


A study using long-term exposure models based on air-pollution monitoring data finds that airborne fine particulate matter (<2.5 μm) is associated with anosmia. Read more »


Smell dysfunction quantified in patients after surgical treatment for acromegaly. Read more »


Selective impairment of orthonasal but not retronasal olfaction in Parkinson’s disease. Read more »


Patients with mastocytosis show reduced olfactory function. Read more »


Olfactory impairment is prevalent in middle-aged subjects with stage I and II obesity. Read more »


Unlike previous, smaller studies, study of 100 patients with mild cognitive impairment finds no change in odor identification performance after treatment with cholinesterase inhibitor. Read more »


Systematic investigation of chemosensory disorders among 65-year-olds in Norway reveals hyposmia in 28% and anosmia in 6%. Read more »


Predictive odor “search images” produced in the posterior pyriform cortex could be a basis for rehabilitation of anosmia due to traumatic brain injury. Read more »


Experimentally induced systemic inflammation does not affect odor identification performance, suggesting that chronic inflammation may underly deficits seen in inflammatory diseases. Read more »


A 48-year-old woman becomes fully anosmic following mild head trauma from bumping into a door at home. Read more »


Deficits in odor detection and identification, as well as taste function, were seen in 212 patients with rheumatoid arthritis. Read more »


Evidence suggests olfactory perception rehabilitation following total laryngectomy (OPRAT) significantly improves smell function in post-op patients. Read more »


Retrospective study of clinic patients finds that etiology of smell dysfunction in children is largely congenital (67%), followed by head trauma (12%) and respiratory infection (6%). Read more »


Prospective study of patients testing positive for SARS-COV-2 finds significant decline in olfactory function during and after infection with most recovering function within 28 days but a quarter showing persistent dysfunction. Read more »


Patient with fever, cough, headache and anosmia tests negative for COVID-19 but turns out to have olfactory groove meningioma. Read more »


Large-scale multicenter European study that Sniffin’ Sticks score predict patients’ quality of life score but that self-assessed olfactory function does so better. Read more »


In older U.S. adults decreased olfactory function is linked to decreased sexual motivation and emotional satisfaction with sex but not to decreased frequency of sexual activity. Read more »


Prospective study of obstructive sleep apnea patients finds improvement in olfactory function with CPAP treatment is negatively correlated with age. Read more »


Adolescents with major depressive disorder have similar olfactory test scores but rate their self-perceived smell function significantly lower. Read more »


Brain MRI imaging of elderly test subjects and young controls links age-related decline in olfactory ability to volume reduction in left parahippocampus. Read more »


Possible compensatory mechanism in higher-order brain regions among congenital anosmics in processing semantic olfactory cues. Read more »


Odor and salt taste impairments more frequent in patients with type 2 diabetes compared to healthy controls. Read more »


Smell Distortion

Case report with imaging of neurological phantosmia following COVID-19 vaccinations. Read more »


Case report of a 14-year-old male diagnosed with olfactory reference syndrome. Read more »


A case of olfactory reference syndrome treated with exposure-based cognitive behavior therapy. Read more »


A 25-year-old female COVID-19 patient experiencing cacosmia and cacoguesia showed no BOLD activation of the orbitofrontal cortex during fMRI with odor stimulation. Read more »


Survey of 521 people in Croatia finds olfactory hallucinations reported in 12% of general population. Read more »


Case study of woman with major depressive disorder treated with venlafaxine who developed severe food-related dysosmia which eventually resolved. Read more »


Neuropsychological examination of nine patients with Olfactory Reference Syndrome revealed deficits in cognitive function, emotional processing, and olfactory function. Read more »


Electrical stimulation of medial orbitofrontal cortex produces pleasant (but illusory) odor perceptions. Read more »


Study of 153 people with post-infectious olfactory dysfunction who received smell training finds presence of parosmia is associated with clinically relevant recovery. Read more »


Smell and taste alterations during cancer chemotherapy may be linked to patient’s treatment stage. Read more »


People with obsessive-compulsive personality disorder more likely than healthy controls to report pleasure, order, and calmness in response to pleasant odors. Read more »


How to distinguish between parosmia and phantosmia in the olfactory symptomology of SARS-CoV-2 infection. Read more »


A series of nine patients with Olfactory Reference Syndrome showed deficits in cognitive and emotional processing as well as odor perception. Read more »


News & Reviews

A systematic review of 74 studies examines differences among measures of olfactory dysfunction associated with frontotemporal dementia, depression, schizophrenia, and bipolar disorder. Read more »


A Summer School on Human Olfaction will be held August 1 through August 6, 2021 in Dresden, Germany. It is organized through the Smell & Taste Clinic of the Department of Otorhinolaryngology of the University of Dresden Medical School. Attendance is limited. For information on lecturers, schedules, fees, and activities click here.


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Review of smell tests used in conjunction with temporal lobe epilepsy concludes that more study is needed to establish the utility and efficacy of odor testing with this condition. Read more »



A review spanning 30 years found 16 studies that examined the effect of septoplasty on the sense of smell. Improved postoperative performance was seen for odor detection, discrimination, and identification. Read more »


Altered odor perception is frequently noted in patients with chronic kidney disease but the etiology and consequences are poorly understood. Read more »


A review of neurotoxicity-related effects on smell and taste finds that with the exception of olfactory impairment after exposure to manganese dust, associations with individual chemicals, therapeutics, and composites remains limited. Read more »


About Us

Disorders of Odor Perception offers links to the latest clinically-relevant science and news about olfactory dysfunction. The most recent items are entered at the top of each section. 

Disorders of Odor Perception does not endorse the material on the linked sites, nor does it offer medical advice. For medical advice about disorders of smell, consult your physician

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